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Once bounded with Ca2 , the vesicles dock and fuse with the presynaptic membrane, and release neurotransmitters into the synaptic cleft by a process known as exocytosis.The neurotransmitters then diffuse across the synaptic cleft and bind to postsynaptic receptors embedded on the postsynaptic membrane of another neuron.Cellular neuroscience is the study of neurons at a cellular level.This includes morphology and physiological properties of single neurons.
These allow Ca2 ions to diffuse through these channels and bind with synaptic vesicles within the terminal boutons.
After neurotransmitters are synthesized, they are packaged and stored in vesicles.
These vesicles are pooled together in terminal boutons of the presynaptic neuron.
Metabotropic receptors on the other hand activate second messenger cascade systems that result in the opening of ion channel located some place else on the same postsynaptic membrane.
Although slower than ionotropic receptors that function as on-and-off switches, metabotropic receptors have the advantage of changing the cell's responsiveness to ions and other metabolites, examples being gamma amino-butyric acid (inhibitory transmitter), glutamic acid (excitatory transmitter), dopamine, norepinephrine, epinephrine, melanin, serotonin, melatonin, and substance P.